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Treatment is generally limited to 812 weeks before cycling off to evaluate response

I.StocchettiN.BullockR

10.1007/s00125-010-1813-x 89 HiraoK.MaruyamaT.OhnoY.HiroseH.ShimadaA.TakeiI.et al (2010)

Schizophrenic patients also exhibit alterations in the distribution of oligodendrocytes and oligodendrocyte cell loss in the superior frontal gyrus, which is in agreement with evidence that multiple genes encoding myelin-related proteins consistently exhibit reduced expression in schizophrenia (Hof et al., 2003)