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GSSSG, but not its related molecule GSSG, known as a principal endogenous antioxidant, significantly inhibited proinflammatory gene upregulation in the retina of LPS-challenged rats

Clinical human studies confirming these findings are still pending

Lysosomal lipid accumulation in vascular smooth muscle cells

Excessive exertion during descent (using vehicles, helicopters, animals, or walk without heavy loads) should be avoided, as it can exacerbate this condition

4.2.2 Tyrosine and phenylalanine metabolism 4.2.2.1 Production and hazards of p-cresyl sulfate (pCS) p-Cresyl sulfate (pCS) is another important protein-bound uremic toxin, formed from p-cresol produced by anaerobic bacterial degradation of tyrosine and phenylalanine through hepatic sulfation or glucuronidation (122)