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Generally, lactylation affects the activity of RNA modification-related enzymes by enhancing transcription activation via histone Kla or directly lactylating these enzymes, eventually regulating RNA modification (Fig

Importantly, a role of Keap1 is to tether Nrf2 to bundles of actin stress fibers which congregate in the cytoplasm at the periphery of the nucleus

Fletcher T, Thompson AJ, Ashrafian H, Darzi A (2022) The measurement and modification of hypoxia in colorectal cancer, overlooked but not forgotten

PPK modeling helps to identify covariates such as age, weight, renal function, or genetic factors that affect the drug exposure measures

Accordingly, dietary management should be stratified