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For example, the R-group carboxyl found in aspartic acid has a pKa value of 3.9 when free in solution, but can be as high as 14 when in certain environments inside of proteins, though that is unusual and extreme

However, during ischemic stroke attack, the expression of Wnt-3a and -catenin is down-regulated, leading to BBB injury [93, 100]

Here we show a neutrally charged nanoprobe with a surface decorated with -glutamyl moieties that can be cleaved by -glutamyl transpeptidase, an enzyme overexpressed on brain capillaries

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