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Cemdisiran and ALN-AAT02 utilize the ESC-GalNAc delivery platform and the ESC-Plus (ESC+)-GalNAc delivery platform, respectively, developed by Alnylam (Figs

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In conjunction with our previous RNA-Seq results, we tried to integrate the three datasets to determine if there were any overlapping genes and pathways that could serve as promising targets, and identified five potential targeting genes, including SATB1, BCAM, GABBR1, MYO7A and MUC3A (Fig