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This includes confirmed low serum vitamin B12 levels, pernicious anaemia, malabsorption states such as coeliac disease, inflammatory bowel disease, or post-gastric or bariatric surgery, unexplained anaemia, neuropathy or neurological symptoms consistent with vitamin B12 deficiency, a long-term vegan diet with symptoms or low levels, or failure of oral vitamin B12 supplementation

Increased uptake of BCKAs by M1 macrophages inhibits the phagocytic capacity of M1 macrophages and may therefore produce immunosuppression

A single low dose of kratom precipitated a modest increase in the systemic exposure to midazolam (CYP3A probe) but not to that of dextromethorphan (CYP2D6 probe)

The GEE was performed to investigate how the efficacies of GSSG, GSH, and placebo varied over time during treatment (Table 2)

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