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10.1016/j.intimp.2020.107132 [DOI] [PubMed] [Google Scholar] Wang Fang W

Cerebral amyloid angiopathy (CAA), which is recognized as a hallmark for AD, is caused by Apo E4 and plays a significant role in the deposition of the A senile plaque additionally, it has been demonstrated that Apo E4 contributed to the development of AD by causing vascular injury in the brain [43]

When acetylcarnitine is injected directly into the brain, most of the acetyl groups were metabolized, as 60% of the injected acetylcarnitine was recovered as exhaled 14 CO 2 after 22 h, and the percentage recovered in the brain was 1.9, 1.6, 1.3, and 0.9% at 1, 3, 6, and 22 h, respectively [109]