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The evidence suggested that increased iron accumulation was negatively associated with cognitive outcomes in chronic TBI patients (Lu et al., 2015)

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Treatment with mGluR1 antagonists (JNJ16259685 or LY367385) decreased repetitive and/or perseverative behaviors (Thomas et al., 2012), and rescued dysregulated synaptic protein synthesis in fragile X mice (Gross et al., 2010

next, cAMP inhibits downstream MEK/ERKMAPK signaling via protein kinase A and suppresses the production of TNF-, a key driving factor for chronic inflammation in IBD