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The most clinically advanced approach is that taken by DIOSynVax (Digitally Immune Optimised Synthetic Vaccines), who have partnered with PharmaJet for a first-in-human needle-free intradermal vaccine pEVAC-PS encoding their synthetic antigen T2_17 based on coronavirus RBD sequences (Table 3) [152]

Both are dominated by gastrointestinal adverse events nausea, vomiting, diarrhea, constipation, and abdominal pain that are mostly mild to moderate and concentrate during dose escalation

It is reliable, well-studied, and easy for the body to process

They have normal acid-base balance

Oral dosing ranges discussed in research community use Phase Weeks 12 (start low) Daily dose 50 mg once daily Notes Morning dosing is the pattern most often reported