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Accumulating evidence has demonstrated that BCAT1, functioning as a key promoter of tumor metastasis and proliferation, holds paramount significance not only in the early detection of tumors but also plays a pivotal role at the treatment phase [45]

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Finally, VEGF secreted in the co-culture system may get bound to the extracellular matrix, where it may not be accessible to VEGF antibodies, but may still be able to be affected by receptor inhibition

Mice ( n = 3) anesthetized by intraperitoneal injection of 2.5% pentobarbital sodium (3.5 mL/kg) were scanned on a 3.0 T MR scanner equipped with a 50 mm 65 mm 8-channel phased-array mouse coil (Shanghai Chenguang Medical Technologies Co., Ltd., Shanghai, China)