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Of these four, ORF7a protein is the most potent NF-B inducer and pro-inflammatory cytokine producer.4 N-acetylcysteine is an antioxidant against reactive oxygen species and is a potent NF-B inhibitor.5 Oral N-acetylcysteine administered at 600 mg thrice daily has been shown to reduce mortality in hospitalised SARS-CoV-2 patients.6 The clinical course of our patient suggests that high-dose N-acetylcysteine antioxidant therapy was able to control the cytokine storm of SARS-CoV-2 infection

10.1042/BCJ20190072 Biochem

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CHIKV supernatant was harvested after 24 h of infection, at which point a clear cytopathic effect was observed

M., Liu, W., Zhang, X