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This legislation firmly states that virtually all medicines administered by injection are automatically designated as Prescription-Only Medicines (POM), creating a powerful legal hurdle that cannot be overcome by simply demonstrating safety through clinical trials alone

Supplementary material The Supplementary Material for this article can be found online at: References 1 AkiyamaS.FukudaS.SteinbergJ

Munc13-4 polymorphism is associated with MAS, sJIA and systemic inflammation, while chronic TLR9 stimulation in mice develops features characteristic of MAS, including elevated serum levels of IFN, interleukin 6 (IL-6) and hepatic inflammation 10