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doi: 10.1016/j.jot.2025.01.012 100 WangHZhaoZSuJChenWShiHGaoTet al

As the first line of immune defense in the CNS, microglia mediate neuroinflammatory responses by releasing pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor- (TNF-), and interleukin-6 (IL-6), disrupting neuronal homeostasis and accelerating the development of morphine tolerance ( Currently, no drugs have been approved for clinical use specifically to prevent or reverse morphine tolerance

Insulin resistance can develop with age and is one of the reasons diabetes is more common in older adults

Consistency: Antioxidant levels build up over time

Given the fairly short half-life of unbound IGF-1 in serum (i.e., 510 min), binding to an IGF binding protein (IGFBP-3 is the most prevalent) in serum or in ECM increases IGF-1 half-life to around 25 min (Allard and Duan, 2019), leading to the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) (O'Neill et al., 2015)