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While recent years has witnessed a growing body of evidences showing demyelinating damages as a critical brain pathological change in neurodegenerative diseases such as Alzheimers disease (Wang et al., 2018) and various neuropsychiatric disorders such as major depression (Williams et al., 2019), schizophrenia (Miyata et al., 2015), and autism (Shen et al., 2018), the most representative and widely studied demyelinating disease is multiple sclerosis (MS)

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Thyroid follicular cells in HT patients can aberrantly express both B7.1 and MHC class II molecules, enabling them to function as non-professional APCs and directly participate in autoimmune activation

Furthermore, when applied to screen pairwise combinations of polymyxin B, polymyxin E, and kanamycin against resistant E

doi:10.1016/j.jcma.2012.09.004 3