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Overall mortality rate at 3 months was 35%

Overcoming these challenges will require advanced delivery platforms such as nanoparticles or hydrogels, personalized stratification tools such as lipidomic and ncRNA signatures, and rigorous pharmacokinetic validation in long-term OA models

Senescent macrophages secrete SASP, such as tumor necrosis factor , IL-1, which are crucial in the development of pulmonary fibrosis [57]

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8.2 Blood and CSF biomarkers Once considered a mere waste product of metabolism, L-lactate is now acknowledged for its various physiological functions in the central nervous system, such as modulating neuronal activity and ensuring energy balance (140, 141)