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The modification with FA and R8 appears to improve therapy efficiency

GST is widely used as a fusion partner that promotes greater expression and solubility of the desired protein by taking advantage of its high stability and solubility to overcome this problem

Oxidation-sensitive linkers leverage elevated reactive oxygen species (ROS) levels in tumor and inflammatory sites, utilizing boronate esters, thioethers, or selenoethers that cleave under oxidative conditions to release drugs

NPs, a distinct subclass of MPs, possess smaller dimensions, a larger surface-to-volume ratio, and greater chemical reactivity than MPs, enhancing their capacity to disrupt metabolism and impair reproduction in animals 15,16

In addition to intrinsic ISC damage, radiation impairs the stem cell niche, which provides critical support signals