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Key Points About Vitamin B12 and Urine Color: The effect of B12 on urine color can depend on the dosage and individual metabolism

A 2025 JAMA Neurology trial (n=1,500) demonstrated a 15-20% reduction in Hamilton Depression Rating Scale (HDRS) scores in deficient adults (serum B12 200 pg/mL and methylmalonic acid (MMA) 0.4 mol/L), with higher doses compensating for poor absorption or severe symptoms like megaloblastic anemia and neuropathy

Vitamin B12 Vitamin B12 helps keep your blood cells healthy

Without intrinsic factor, the small intestine cannot efficiently absorb dietary B12 through the normal receptor-mediated pathway

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