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In naturally aged mice, the renal function improvements were statistically significant but more modest a pattern consistent with the lower but still meaningful senescent cell burden in normal aging

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Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

Figure 2 The temporal distribution of publications, shown in Figure 3, reveals a clear upward trend in research activity over time

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