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It plays an indispensable role in DNA synthesis, red blood cell formation, and neurological function ( Figure 1 Vitamin B12 deficiency, defined as ciculatory B12 level below 150200 pg/mL (borderline 200300 pg/mL) (Figure 2), including megaloblastic anemia and irreversible neurological damage ( Figure 2 For individuals at risk of B12 deficiency, treatment is often necessary to maintain adequate circulatory levels ( Thus, an optimized carrier system is crucial for enhancing the bioavailability of supplemental oral supplemental B12

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Folate status is highly dependent on whether the country of residence has a mandatory folic acid (FA) food fortification policy