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Oxidative stress, mitochondrial dysfunction and glutamate excitotoxicity may also interact as a feed-forward vicious cycle (Nguyen et al, 2011) : Our results conclusively demonstrate that not only glutamate excitotoxicity and/or oxidative stress alters mitochondrial fission/fusion, but that an imbalance in mitochondrial fission/fusion in turn leads to NMDA receptor upregulation and oxidative stress