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People following a vegetarian or vegan diet, however, should be aware that they are at a higher risk of B12 deficiency due to this lack of B12 in plant foods

Neuropathy Treatment Pricing (Vitamin B12 Injection Programme) Initial Consultation 65 A mandatory assessment to ensure treatment safety and suitability, including: Neurological & vascular foot assessment Medication & medical history review Screening for B12 deficiency risks Personalised treatment plan Required for all patients before beginning treatment

Mechanism of Action and Target Biology NNMT Enzyme and Function: Nicotinamide N-methyltransferase (NNMT) catalyzes the SAM-dependent methylation of nicotinamide: Reaction: Nicotinamide + SAM 1-methylnicotinamide (1-MNA) + S-adenosylhomocysteine (SAH) Expression: Liver, adipose tissue (particularly visceral), smooth muscle, some neurons Regulation: Increased expression in obesity, diabetes, aging, certain cancers Substrates consumed: Nicotinamide (NAD+ precursor) and SAM (methyl donor) 5-Amino-1MQ Inhibition Mechanism: Competitive inhibitor with respect to nicotinamide substrate IC: Submicromolar range for NNMT enzyme Selectivity: Minimal inhibition of other methyltransferases at relevant concentrations Result: Increased intracellular nicotinamide availability for NAD+ salvage pathway Downstream Effects of NNMT Inhibition: 1

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