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The authors further demonstrated the role of TLR-4 in mediating brain injury by generating mice lacking TLR-4 in microglia

The ratio of GSH to GSSG serves as an indicator of cellular health and oxidative stress levels

In the electron transport chain (ETC), oxygen is partially reduced by the incorporation of an electron, generating a free radical as a secondary product (Venditti et al., 2013)

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In addition, TMT exposure can trigger neuroinflammatory responses, characterized by increased levels of pro-inflammatory cytokines such as TNF-, IL-1, and nitric oxide, and increased gene expression of the glial fibrillary acidic protein and activated microglia in the brain