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AOD-9604s lipolytic effect is blunted during caloric surplus because elevated insulin suppresses hormone-sensitive lipase regardless of beta-3 receptor stimulation

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In young healthy subjects (n = 80, age 25.4 0.2), this effect is achieved with higher doses and is correlated with L-arginine plasma concentrations ( From clinical trials testing the effects of oral administration of L-arginine, a picture has emerged that short-term L-arginine administration (3 months) provides benefits, whereas longer supplementation (6 months) gives mixed results