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Two randomized controlled trials, three prospective papers, one systematic review, and three clinical reviews fulfilled our inclusion criteria

A contaminated oral supplement is concerning

studies show that even high oral doses may not significantly raise systemic levels in a robust way

Established research on intranasal peptide delivery exists for oxytocin, insulin, and several neuropeptides

Possible side effects particularly with a known allergy to plants of the daisy family (Asteraceae): Bloating and abdominal pain Diarrhoea Stomach cramps and nausea Headaches (rare) These symptoms typically resolve quickly after discontinuing milk thistle and leave no lasting effects