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Targeting -secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

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(K) Western blot analysis of p-p38, p38, CyclinA2, IL6, and Flag on day W11 in NCI-H446 cells overexpressing Flag-CRIP1 WT/R16K/R16F with Ana from W8 to W11

Although the roles of glia in neurodegeneration are becoming more apparent, the understanding of the autophagylysosome system in these cells is less developed in the context of neurodegenerative diseases