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Then, they are infiltrated via the surrounding stroma favoring the pathways, leading to degradation of ECM [18]

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[] Its expression is upregulated by HIF-1 and forkhead box protein O3 (FOXO3)

An overview on the effects of some carotenoids on health: lutein and Zeaxanthin

So far, the FDA has primarily approved treatments for AD that focus on compensating for cholinergic neuron loss using drugs such as inhibitors for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), including medications like tacrine, donepezil, rivastigmine, and galantamine, as well as the glutamatergic drug memantine, which functions as an N-methyl-D-aspartate (NMDA) receptor antagonist (Albertini et al