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The metabolic programs of T cells undergo significant changes during their activation and depletion (136)

There is an accumulating body of evidence to suggest that choledocholithiasis can be managed during a single procedure by incorporating intraoperative cholangiography (IOC) with laparoscopic common bile duct exploration (LCBDE) at the time of cholecystectomy (LC with IOC LCBDE)

Matsuyama et al., 2017)

Then, the pyrimidine ring and 5-pyriphosphoribosyl pyrophosphate (5-PRPP), generated from the pentose phosphate pathway (PPP), are catalyzed to form orotidine 5-monophosphate (OMP) via dihydroorotate dehydrogenase (DHODH)

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