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3) Immune regulationsupports balanced immune cell function and reduces excessive inflammation

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While the molecular pathogenesis of AxD remains incompletely understood, massive reactive astrogliosis with Rosenthal fibers composed of aggregated GFAP, vimentin, nestin, B-crystallin and small heatshock proteins together with prominent leukodystrophy are the pathological hallmarks, with the pathophysiological picture including mitochondrial malfunction, redox imbalance and susceptibility to oxidative stress 331,332,333

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In a dose-ranging study in ESRD patients undergoing hemodialysis, patients received 10, 20, or 40 mg/kg Levocarnitine 3 times per week following dialysis (N~30 for each dose group)