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On this basis, it appears clear how the ozone generated ROS and LOPs at the ALL level, after being minimally quenched by the insufficient, antioxidants will act as cell signals able to activate nuclear factor-kappa B (NF-B), NO-synthase, some protein kinases, thus enhancing the synthesis and release of TNF, IL-1, IL-8, IFN and TGF1 and the possible formation of nitrating species

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