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-GT is located at luminal endothelial cell membranes of these organs with its active site on the extracellular surface of the membrane rightly positioned for the cleavage of GSH from the blood circulation (Fig

Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia

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We generated mice with IEC-specific deletion of one Gpx4 allele ( Gpx4 +/IEC ), which is a valuable tool for modeling the effects of reduced, but not completely abrogated epithelial GPX4 activity as observed in patients with small intestinal CD

Animal results are useful for generating hypotheses