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Materials and Methods Test Compounds All compounds including astemizole, chlorpromazine, chloroquine, clomipramine, desipramine, fluoxetine, imipramine, nortriptyline, paroxetine, sertraline, thioridazine, dimethylsulfoxide (DMSO), bafilomycin A (BFA) and rapamycin were purchased from Sigma Aldrich (St

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

ULK1 then phosphorylates both ATG13 and FIP200, triggering the recruitment of the BECLIN-1VPS34 complex to the pre-autophagosomal membrane and facilitating autophagosome formation