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Endocrinology 153 , 29452948 (2012)

Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]

Differentially abundant ruminal metabolites in RPG group were predominantly enriched in host-centric signaling pathways, including MAPK signaling, growth hormone synthesis/secretion, and NF-B signaling, rather than microbial primary metabolic pathways [73]

An aliquot of 50 mL cell culture was centrifuged at 4C and 7,000 g for 5 min and then washed twice with distilled water