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Isolated WBCs were diluted in PBS (1) at a final concentration of 2 10 6 /ml

The damage caused by unchecked oxidative stress extends beyond the mitochondria to other vital cellular structures, particularly the peroxisomes and lipid membranes

Recently, an interesting study identified dihydroorotate dehydrogenase (DHODH) as a novel ferroptosis suppressor that functions as independent of the classical GPX4 signaling pathway and revealed the mitochondrial lipid peroxidation-dependent ferroptosis pathway [79]

*Correspondence: Olivier Tabary, [email protected] This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Instead, asparagine supplementation enhances the expression of glutamine synthetase (GLUL) and increases intracellular glutamine usage via glutaminolysis, resulting in the recovery of global protein translation that is blocked by glutamine deprivation 45