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Inactivation of the detoxifying enzyme glutathione -S- transferase has been observed in cells exposed in vitro to busulfan and, because of the inactivation of the enzyme, the level of free electrophilic species in the tissues of the exposed organisms can increase to levels that irreversibly damage the cell, which is deranged to apoptotic or necrotic death

However, there are few studies regarding this topic, probably because the complete repertoire of isoenzymes has not been elucidated in the species of interest

Its often used to support immune function, particularly during times of high stress or seasonal illness

Among them, there are different types of compounds with different places amodesode of action and varied final effects (Sharifi-Rad et al., 2022)

Both compounds could dock into the glutathione-recognizing domain of the enzymes, the serine analogue showing a higher affinity than the locally apolar alanine analogue [133]