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A recent Cochrane review of these trials, involving 153 patients, found comparable serum B12 levels in patients taking either route (Wang et al., 2018)

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Additionally, in Shank3/ mice, the expression levels of glutamate receptors are reduced in the striatum and thalamus, although no changes in the cell surface expression of GABAA receptor 1 subunits were observed in the cortex, striatum, thalamus, or cerebellum (93)

Consequently, understanding the unique mutations of each VoC is a pressing concern for the global public health