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Description

J Dig Dis 15:517524

Valproate itself has multiple actions including modifying GABA levels by inhibiting 4-aminobutyrate aminotransferase (ABAT, GABA transaminase) and aldehyde dehydrogenase five family member A1 (ALDH5A1) which degrades GABA, thereby increasing inhibitory GABA availability

The classic example is active acromegaly, but prolonged high dose s.c

R., Fallas, J

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