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Mller, T

14.7 Treatment of Pulmonary Embolism in Adult Patients In a randomized, open-label, clinical trial in patients with a confirmed diagnosis of acute symptomatic PE, with or without DVT, fondaparinux sodium 5 mg (body weight less than 50 kg), 7.5 mg (body weight 50 kg to 100 kg), or 10 mg (body weight greater than 100 kg) subcutaneously once daily (fondaparinux sodium treatment regimen) was compared to heparin IV bolus (5,000 USP units) followed by a continuous IV infusion adjusted to maintain 1.5 to 2.5 times aPTT control value

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For more advanced or custom uses of the eXpress UDI Module, where the knowledge of the design is captured within the eXpress model, the UDI capability can be used to effectively augment known diagnostic inadequacies or be used to consistently facilitate maintenance requirements or specific programmatic procedural actions

Increasing the ingested dose above 5 g should be avoided since this will alter intestinal motility and water handling through its osmotic effect