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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

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Studies show that high glutathione levels increase muscle strength, shorten muscle recovery time and consequently reduce muscle damage

Zulfiqar F, Ashraf M (2021) Bioregulators: Unlocking their potential role in regulation of the plant oxidative defense system

Despite significant advances in understanding mitochondrial function, the complexity of these functions and the disturbances caused by their defects remain critical issues