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doi: 10.1006/bbrc.1996.1188

As a cell surface receptor, CD38 is necessary for immune cell activation and proliferation

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In relapsed or refractory myeloma (R/R MM) patients, the CD38 expression levels are relatively high in NK cells, regulatory B cells (Bregs), Tregs and myeloid-derived suppressor cells (MDSCs) compared with CD8 + and CD4 + T cells, indicating that CD38 is involved in providing the immunosuppressive environment for tumor growth [19]