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On the subject, increased sensitization of human TRPA1 in DRG neuron was reported by inflammation and oxidative stress, although the increased sensitization in the neuron is decreased by antioxidant NAC and capsazepine (Kistner et al., TRPM2 Another member of TRP superfamily is TRPM2

However, there is no evidence that enforcing reduction of these sensors is sufficient for their activation, meaning there would then be no reason to expect DCA to cause ER stress on its own

doi: 10.1530/rep.1.00941 88 MalekinejadHZeynali-MoghaddamSRezaei-GolmishehAAlenabiAMalekinejadFAlizadehAet al

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