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tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells

The key inductive role of metabolic activation in toxicity is highlighted, and frequently toxic functional groups of toxic natural products were summarized

Acknowledgements This work are financially supported by Chongqing Research Program (cstc2018jcyjAX0742) of Basic Research and Frontier Technology, Scientific and Technological Research Program (KJQN201900521) of Chongqing Education Committee, Scientific Research Fund (2019YJ0307) of Sichuan Provincial Science and Technology Department and Dazhou Municipal Science Project (18YYJC0002) of Technology Bureau Application Foundation

Jusqu' prsent, ni les autorits sanitaires, ni l'OMS, ne semblent s'tre penches srieusement sur les dangers spcifiques de ces injections, contrairement ceux des crmes, largement documents