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a,b,c Mechanistically, the At LDOX catalysed hydroxylation of 3,4- cis -leucocyanidin ( 6 ) may result in hydroxylation products at C 2 ( a ), C 3 ( b ) or C 4 ( c )

Differentially expressed genes selected from RNAseq data

MTHFR has two forms, heterozygous or homozygous

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These findings suggest that TRPML1 is a potential therapeutic target, and inducing ferroptosis by regulating TRPML1 is important for the treatment of AKT-hyperactivated cancer