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doi: 10.1016/j.bioactmat.2023.09.021

2017;11;32(6):869883.e5

Pediatric Use in CIRS-like Presentations Although the Shoemaker Protocol is typically validated in adult populations, a subset of pediatric patients with autism spectrum disorder (ASD), PANS/PANDAS, or idiopathic neuroinflammatory syndromes may fulfill criteria for CIRS

Leonetti HB, Landes J, Steinberg D, Anasti JN

NR is backed by extensive clinical research demonstrating safety, bioavailability, and benefits for healthy aging, unlike direct NAD+ supplements, which lack solid human data