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Moreover, estrogen was reported to regulate proteolysis through the induction of protease inhibitors, preventing excessive degradation of extracellular matrix components that are essential for tissue repair (Horng et al., 2017)

DAO uses copper as a cofactor and requires vitamin B6 (in its P5P form) to function optimally. 24 Multiple SNPs in AOC1 have been associated with significantly reduced DAO activity and histamine intolerance

Increased levels of prostaglandin E2 (PGE 2 ) were demonstrated in homogenized small bowel biopsy specimens from patients with active celiac disease [34] while the levels of the antioxidant enzyme glutathione peroxidase and reductase were decreased in biopsies from celiac disease patients with consequent decreased levels of GSH [35,36,37] (Table 1)

Patients should not begin a new cycle of treatment unless the ANC is = 1500 cells/mm3, the platelet count is = 100,000 cells/mm3 and creatinine clearance is = 45mL/min