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The primary concern is the indiscriminate biodistribution of traditional antimicrobials, which may result in dose-limiting off-target toxicity, thereby impacting beneficial commensal microbiomes and causing detrimental effects including dysbiosis ( In addition to their cytotoxic effects, many small-molecule agents exhibit insufficient penetration into critical sanctuary sites, including granulomas, the blood-brain barrier (BBB), and various intracellular compartments, where pathogens can persist and facilitate relapse (Pardridge, 2020

Surfactants with charged hydrophilic ends are known as ionic surfactants, classified into three categories based on the nature of their charges: Cationic surface active agent Cationic surfactants are mainly divided into ammonium salt types and quaternary ammonium salt types

otherwise, see the standalone overviews)

It is non-invasive, requires no downtime, and is often used prior to injection therapy or as a standalone treatment option

Weekly at-home injection with clinician oversight and check-ins