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The phase 2 clinical trial NCT03485209 is currently evaluating patients with solid tumors treated with tisotumab in combination with other antineoplastic agents, although breast cancer is not included [118, 119]

The toxins, enzymes and metabolites of bacteria (predominantly Gram-negative anaerobic) present in the dental plaque play a key role in the initiation of the inflammatory process, but the exact pathomechanism is far from being understood in detail (5-8)

Shibata N, Kunisawa J, Hosomi K et al (2018) Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity

It is commonly explored within experimental models involving musculoskeletal biology, wound healing mechanisms, and regenerative processes

Gluteofemoral depot A representative, commonly studied human subcutaneous adipose depot