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Heterozygous IGFALS gene variants in idiopathic short stature and normal children: impact on height and the IGF system

The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

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PI3K, on the other hand, is responsible for the insulin-like actions of the hormones by activating Akt/protein-kinase B (PKB) and protein-kinase C (PKC), which subsequently leads to activation of p70 S6K and glycogen-synthase kinase 3[252]