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10.56984/8ZG20BSbq Fizjoterapia Polska

Retatrutide: Complication Focus TRIUMPH-4: Obesity + knee osteoarthritis (445 participants) TRIUMPH-2: Obesity + type 2 diabetes TRIUMPH-6: Weight maintenance trial Advantage: Multiple complication-specific trials could lead to broader label (obesity + OA + OSA indications)

Varadi, A

Abbreviations BPH: Benign prostatic hyperplasia LUTSs: Lower urinary tract symptoms OS: Oxidative stress DEGs: Differentially expressed genes MXRA5: Matrix-remodeling associated 5 CXCL13: C-X-C Motif Chemokine Ligand 13 BMP5: Bone morphogenetic protein 5 NELL2: Neural epidermal growth factor-like like 2 GPX3: Glutathione peroxidase 3 GSH: Glutathione ROS: Reactive oxygen species Cyto-C: Cytochrome c MMP: Mitochondrial membrane potential PCD: Programmed cell death MDA: Malondialdehyde H&E: Hematoxylin and eosin staining IHC: Immunohistochemical DMSO: Dimethyl sulfoxide T: Testosterone propionate RSL3: RAS-selective lethal 3 GPX4: Glutathione peroxidase 4 TRO: Troglitazone PPAR: Peroxisome proliferator-activated receptor Rapa: Rapamycin CQ: Chloroquine Nrf2: Nuclear factor erythroid 2-related factor 2 SOD2: Superoxide dismutase 2

[DOI] [PubMed] [Google Scholar] 203.Neelakantan, H