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Excessive autophagy can lead to metabolic stress and degradation of cellular components, which exacerbates the structural destruction and functional decline of tissues ( 2 O 2 -induced autophagy with a decreased expression of autophagy marker proteins LC3-II and Beclin-1

After two weeks of dietary intervention, rats on the HFD were given a single injection of STZ [35 mg/kg/intraperitoneal (i.p.)]

The metabolic fates of amino acids and the formation of glutamine in skeletal muscle

Fibromyalgias complex nature, involving central sensitization, neuroinflammation, mitochondrial dysfunction, and altered pain processing, requires therapeutic strategies capable of healing at a foundational level

James-Martin, and colleagues