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In this protocol, we favor a functional definition of SLP dependency as the comparatively limited capacity of malignant cells to sustain long-term proliferation when forced to use OXPHOS-exclusive metabolism (e.g., deprivation of glucose and glutamine, the two primary SLP fuels, at the substrate, transport, or utilization level)

Angiogenesis inhibitors: A type of targeted therapy that is being studied in the treatment of melanoma

The authors acknowledge additional financial support from the UK Department of Health and Cancer Research UK via Experimental Cancer Medicine Center awards to Kings Health Partners/Guys & St Thomas NHS Foundation Trust (JS)

Clinical studies indicate minimum 2% concentration is required for measurable melanin inhibition

Henley, J